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货号： bs-6081R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6081R-AF555
- 英文名称
- Anti-PDGFRL/AF555
- 中文名称
- AF555标记的血小板源性生长因子受体β样蛋白抗体
- 别 名
- PDGF receptor beta like tumor suppressor; PGFRL_HUMAN; PDGFR-like protein; PDGRL; PRLTS.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 40kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PDGFRL
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This protein is expressed in colon, lung and liver. Defects in PDGFRL are associated with colorectal cancer.
Subunit:
Forms a complex composed of PDGFRL, TNK2 and GRB2.
Subcellular Location:
Secreted (Probable).
Tissue Specificity:
Expressed in colon, lung and liver.
DISEASE:
Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene represented in this entry is involved in disease pathogenesis.
Note=A polymorphism in PDGFRL has been reported to be associated with susceptibility to Behcet disease (PubMed:19815557). Behcet disease is a complex multiple-system disorder characterized by recurrent oral ulcerations, recurrent genital ulcerations, typical skin lesions, and uveitis. Behcet disease also involves joints, blood vessels, musculoskeletal, neurological systems, and the gastrointestinal tract.
Similarity:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Database links:Entrez Gene: 5157 Human
Entrez Gene: 68797 Mouse
Entrez Gene: 515017 Cow
GenBank: NP_006198.1 Human
Omim: 604584 Human
SwissProt: Q5BIP2 Cow
SwissProt: Q15198 Human
SwissProt: Q2PFX1 Monkey
SwissProt: Q6PE55 Mouse
Unigene: 458573 Human
Unigene: 284246 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.