产品中心
当前位置：首页>产品中心Anti-CAMK1D/AF555
货号： bs-6225R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6225R-AF555
- 英文名称
- Anti-CAMK1D/AF555
- 中文名称
- AF555标记的钙调蛋白激酶CaMK1D抗体
- 别 名
- Calcium/calmodulin dependent protein kinase ID; Calcium/calmodulin dependent protein kinase type 1D; CaM K1; CaM KI delta; CaM kinase I delta; CaM kinase ID; CAMK 1D; Camk1D; CaMKI delta; CamKI like protein kinase; CaMKID; CKLiK.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 43kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CAMK1D
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
CAMK1D is a member of the Ca2+/calmodulin-dependent protein kinase 1 subfamily of serine/threonine kinases. It may be involved in the regulation of granulocyte function through the chemokine signal transduction pathway and may play a role in apoptosis of erythroleukemia cells.
Function:
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Phosphorylates the transcription activator CREB1 on Ser-133 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.
Subcellular Location:
Cytoplasm. Nucleus. Predominantly cytoplasmic (Probable). Also nuclear upon activation.
Tissue Specificity:
Broadly expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes.
Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Contains 1 protein kinase domain.
Database links:Entrez Gene: 57118 Human
Entrez Gene: 227541 Mouse
Entrez Gene: 307124 Rat
Omim: 607957 Human
SwissProt: Q8IU85 Human
SwissProt: Q8BW96 Mouse
Unigene: 659517 Human
Unigene: 191949 Mouse
Unigene: 200021 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.