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货号： bs-6248R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6248R-AF555
- 英文名称
- Anti-IMPAD1/AF555
- 中文名称
- AF555标记的肌醇单磷酸酶IMPA3抗体
- 别 名
- IMP 3; IMPA3; IMPase 3; Inositol monophosphatase domain containing protein 1; Myo inositol monophosphatase A3.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 39kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human IMPAD1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1.
Function:
May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3,5-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation
Subcellular Location:
Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein.
Post-translational modifications:
Contains N-linked glycan resistant to endoglycosydase H.
DISEASE:
Defects in IMPAD1 are the cause of chondrodysplasia with joint dislocations GPAPP type (CDP-GPAPP) [MIM:614078]. A condition consisting of congenital joint dislocations, chondrodysplasia with short stature, micrognathia and cleft palate, and a distinctive face.
Similarity:
Belongs to the inositol monophosphatase family.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.