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货号： bs-6286R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6286R-AF555
- 英文名称
- Anti-TMPRSS4/AF555
- 中文名称
- AF555标记的膜型丝氨酸蛋白酶2抗体
- 别 名
- MT SP2; Membrane type serine protease 2; TMPRSS 4; TMPRSS3; Transmembrane protease, serine 4; Transmembrane serine protease 3; UNQ776/PRO1570; TMPS4_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导 肿瘤细胞生物标志物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 48kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TMPRSS4 (84-130aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
TMPRSS4 is a member of the peptidase S1 family and contains 1 LDL receptor class A domain, 1 peptidase S1 domain and 1 SRCR domain. It is a probable membrane protease capable of activating ENaC and may process sodium channels in endothelial cells. TMPRSS4 is overexpressed in thyroid neoplasms, and splice variants in TMPRSS4 are thought to be linked with different cancers. Three named isoforms are produced by alternative splicing.
Function:
Probable protease. Seems to be capable of activating ENaC.
Subcellular Location:
Membrane; Single-pass type II membrane protein (Potential).
Tissue Specificity:
High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract.
Similarity:
Belongs to the peptidase S1 family.
Contains 1 LDL-receptor class A domain.
Contains 1 peptidase S1 domain.
Contains 1 SRCR domain.
Database links:Entrez Gene: 451581 Chimpanzee
Entrez Gene: 489387 Dog
Entrez Gene: 101147411 Gorilla
Entrez Gene: 100071190 Horse
Entrez Gene: 56649 Human
Entrez Gene: 100390415 Marmoset (common)
Entrez Gene: 100436934 Orangutan
Omim: 606565 Human
SwissProt: Q9NRS4 Human
Unigene: 161985 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.