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货号： bs-6502R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6502R-AF555
- 英文名称
- Anti-Testin/AF555
- 中文名称
- AF555标记的肿瘤抑制基因Testin抗体
- 别 名
- Testin; TES; TESS 2; TESS; TESS2; TESS-2; Testis derived transcript (3 LIM domains); Testis derived transcript; TES_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 信号转导 转录调节因子 锌指蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 48kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Testin (161-210aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Cancer-associated chromosomal changes often involveregions containing fragile sites. This gene maps to a commomfragile site on chromosome 7q31.2 designated FRA7G. This gene issimilar to mouse Testin, a testosterone-responsive gene encoding aSertoli cell secretory protein containing three LIM domains. LIMdomains are double zinc-finger motifs that mediate protein-proteininteractions between transcription factors, cytoskeletal proteinsand signaling proteins. This protein is a negative regulator ofcell growth and may act as a tumor suppressor. This scaffoldprotein may also play a role in cell adhesion, cell spreading andin the reorganization of the actin cytoskeleton. Multiple proteinisoforms are encoded by transcript variants of this gene.
Function:
Scaffold protein that may play a role in cell adhesion,cell spreading and in the reorganization of the actin cytoskeleton.Plays a role in the regulation of cell proliferation. May act as atumor suppressor. Inhibits tumor cell growth.
Subunit:
Interacts via LIM domain 1 with ZYX. Interacts (via LIMdomain 3) with ENAH and VASP. Interacts with talin, actin,alpha-actinin, GRIP1 and PXN. Interacts (via LIM domain 2) withACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimerinteracts with ENAH to form a heterotrimer.
Subcellular Location:
Cytoplasm. Cell junction, focal adhesion.Note=Detected along actin stress fibers.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the prickle / espinas / testin family.
Contains 3 LIM zinc-binding domains.
Contains 1 PET domain.
Database links:Entrez Gene: 534965 Cow
Entrez Gene: 26136 Human
Entrez Gene: 21753 Mouse
Entrez Gene: 500040 Rat
Omim: 606085 Human
SwissProt: Q2YDE9 Cow
SwissProt: Q2QLB2 Horse
SwissProt: Q9UGI8 Human
SwissProt: P47226 Mouse
SwissProt: Q2QLE3 Pig
SwissProt: Q2LAP6 Rat
Unigene: 592286 Human
Unigene: 664957 Human
Unigene: 436548 Mouse
Unigene: 44847 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.