产品中心
当前位置：首页>产品中心Anti-SPON1/AF555
货号： bs-7520R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7520R-AF555
- 英文名称
- Anti-SPON1/AF555
- 中文名称
- AF555标记的细胞外基质底物反应蛋白1抗体
- 别 名
- F spondin; F spondin extracellular matrix protein; FSPO; KIAA0762; MGC10724; SPON 1; spondin 1 (f spondin) extracellular matrix protein; Spondin 1; Spondin 1 extracellular matrix protein; Spondin 1 precursor; Spondin1; Vascular smooth muscle cell growth promoting factor; VSGP; VSGP/F spondin.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 神经生物学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 86kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SPON1/F spondin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
SPON1 is a member of a subgroup of the thrombospondin type 1 (TSR) class molecules, defined by two domains of homology, the FS1/FS2 and TSR domains. The TSRs of SPON1 proteins are typical of class 2 TSRs. SPON1, which is similar to thrombospondin, is a extracellular matrix attached molecule that promotes neurite outgrowth and inhibits angiogenesis. Analysis of gain and loss of function experiments reveal that SPON1 is required for accurate pathfinding of embryonic axons, and plays a dual role in patterning axonal trajectories. It promotes the outgrowth of commissural and inhibits the outgrowth of motor axons, and has also been implicated in inflammatory processes in the nervous system.
Subunit:
Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP.
Subcellular Location:
Secreted, extracellular space, extracellular matrix.
Tissue Specificity:
Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen.
Similarity:
Contains 1 reelin domain.
Contains 1 spondin domain.
Contains 6 TSP type-1 domains.
Database links:
UniProtKB/Swiss-Prot: Q9HCB6.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.