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货号： bs-6763R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6763R-AF555
- 英文名称
- Anti-MSR1/AF555
- 中文名称
- AF555标记的巨噬细胞清道夫受体1抗体
- 别 名
- CD204; SP-A; CD204 antigen; Macrophage acetylated LDL receptor I and II; Macrophage scavenger receptor 1; Macrophage Scavenger Receptor I; Macrophage scavenger receptor type III; Macrophage scavenger receptor types I and II; Msr 1; MSR1; MSRE_HUMAN; phSR1; phSR2; SCARA 1; SCARA1; Scavenger receptor class A member 1; Scavenger receptor type A; Scvr; SR A; SRA.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 50kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MSR1/CD204
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimers disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
Function:
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL.
Subunit:
Homotrimer.
Subcellular Location:
Membrane; Single-pass type II membrane protein.
Tissue Specificity:
Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages.
DISEASE:
Defects in MSR1 may be a cause of prostate cancer (PC)[MIM:176807]. A malignancy originating in tissues of the prostate.Most prostate cancers are adenocarcinomas that develop in the aciniof the prostatic ducts. Other rare histopathologic types ofprostate cancer that occur in approximately 5% of patients includesmall cell carcinoma, mucinous carcinoma, prostatic ductalcarcinoma, transitional cell carcinoma, squamous cell carcinoma,basal cell carcinoma, adenoid cystic carcinoma (basaloid),signet-ring cell carcinoma and neuroendocrine carcinoma. Note=MSR1variants may play a role in susceptibility to prostate cancer. MSR1variants have been found in individuals with prostate cancer andco-segregate with the disease in some families.
Defects in MSR1 may be a cause of Barrett esophagus (BE)[MIM:614266]. A condition characterized by a metaplastic change inwhich normal esophageal squamous epithelium is replaced by acolumnar and intestinal-type epithelium. Patients with Barrettesophagus have an increased risk of esophageal adenocarcinoma. Themain cause of Barrett esophagus is gastroesophageal reflux. Theretrograde movement of acid and bile salts from the stomach intothe esophagus causes prolonged injury to the esophageal epitheliumand induces chronic esophagitis, which in turn is believed totrigger the pathologic changes. Note=Genetic variants in MSR1 havebeen found in individuals with Barrett esophagus and are thought tocontribute to disease susceptibility.
Similarity:
Contains 1 collagen-like domain.
Contains 1 SRCR domain.
Database links:Entrez Gene: 281311Cow
Entrez Gene: 4481Human
Entrez Gene: 498638Rat
Omim: 153622Human
SwissProt: P21758Cow
SwissProt: P21757Human
Unigene: 147635Human
Unigene: 231068Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.