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货号： bs-6765R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6765R-AF555
- 英文名称
- Anti-Perilipin A+B/AF555
- 中文名称
- AF555标记的脂滴包被蛋白A+B抗体
- 别 名
- Lipid droplet associated protein; PERIA; PERIB; Perilipin A; Perilipin; Perilipin B; PerilipinA; PerilipinB; PLIN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 细胞生物 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Chicken, SheepDog,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 54-56kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Perilipin A+B
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Perilipin is an intracellular neutral lipid droplet protein that is hormonally regulated. This protein is localized exclusively to the surface of lipid droplets. In response to lypotic stimuli, perilipin is phosphorylated by protein kinase A. Once activated, perilipin has inhibitory affects upon hormone-sensitive lipase (HSL), a protein that mediates the hydrolysis of triacylglycerol, the major form of stored energy in the body. Perilipin expression is limited to adipocytes and steroidogenic cells. There are currently two known isoforms, Perilipin A and B. Both of these proteins are encoded by a single-copy gene and are the result of differential splicing events.
Function:
Perilipin A: Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness.
Perilipin B: May be involved in development and maintenance of adipose tissue.
Subunit:
Perilipin A: Interacts with ABHD5.
Subcellular Location:
Perilipin A: Lipid droplet. Note=Lipid droplet surface-associated.
Perilipin B: Membrane; Peripheral membrane protein.
Tissue Specificity:
Perilipin A: Adipocytes.
Perilipin B: Milk lipid globules.
Post-translational modifications:
Perilipin A: Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet.
Perilipin B: Acylated; primarily with C14, C16 and C18 fatty acids.
DISEASE:
Perilipin A: Defects in PLIN1 are the cause of familial partial lipodystrophy type 4 (FPLD4) [MIM:613877]. FPLD4 is a form of lipodystrophy characterized by loss of subcutaneous adipose tissue primarily affecting the lower limbs, insulin-resistant diabetes mellitus, hypertriglyceridemia, and hypertension.
Perilipin B:
Similarity:
Perilipin A: Belongs to the perilipin family.
Perilipin B: Belongs to the perilipin family.
Database links:Entrez Gene: 5346 Human
Entrez Gene: 103968 Mouse
Entrez Gene: 25629 Rat
Omim: 170290 Human
SwissProt: O60240 Human
SwissProt: Q8CGN5 Mouse
SwissProt: P43884 Rat
Unigene: 103253 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.