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货号： bs-6858R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6858R-AF555
- 英文名称
- Anti-Caspase 4+Caspase 11/AF555
- 中文名称
- AF555标记的半胱胺酸蛋白酶4/11抗体
- 别 名
- CASP11;CASP11;Casp4;Caspase 11;Caspase11;Caspase-11;Caspase 4;Caspase4;Caspase-4;Caspase 4 apoptosis related cysteine peptidase;CASPL;CASPL;Ich3;ICH3 protease;ICH3 protease.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 20kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse Caspase-4 subunit p20
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Caspase 11 (also known as ICH3) gene encodes two protein products of 38 and 43 kDa that belong to the Ced3/ICE family of cysteine proteases. Caspase 11 is an “upstream” caspase with a long prodomain. It undergoes a cleavage upon activation, leading to p20 and p10 subunits. Monoclonal antibodies reacting specifically with caspase 11 are useful tools for the study of the protease network, involved in development and regulation, governing the life and death of cells and tissues.
Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Promotes IL-1 beta processing by ICE, so may also have a role in inflammatory responses.
Subunit:
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit.
Tissue Specificity:
Mostly expressed in lung and spleen; weaker in heart and lung; little in liver, skeletal muscle, kidney and testis. Not found in the brain.
Post-translational modifications:
The two subunits are derived from the precursor sequence by a autocatalytic mechanism.
Similarity:
Belongs to the peptidase C14A family.
Contains 1 CARD domain.
Database links:Entrez Gene: 837 Human
Entrez Gene: 12363 Mouse
Omim: 602664 Human
SwissProt: P49662 Human
SwissProt: P70343 Mouse
Unigene: 138378 Human
Unigene: 1569 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.