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货号： bs-6770R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6770R-AF555
- 英文名称
- Anti-DRAK1/AF555
- 中文名称
- AF555标记的丝氨酸/苏氨酸蛋白激酶17A/DAP凋亡诱导蛋白激酶1抗体
- 别 名
- DAP kinase-related apoptosis-inducing protein kinase 1; death-associated protein kinase-related 1; EC 2.7.11.1; Serine / threonine kinase 17a death associated protein kinase related 1; Serine/threonine kinase 17a; Serine/threonine protein kinase 17a; STK17 A; STK17A; ST17A_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 细胞凋亡 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 50kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DRAK1/STK17A
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
DRAK1 (DAP kinase-related apoptosis-inducing protein kinase 1) is a novel member of the ser/thr protein kinase family, which mediate apoptosis through their catalytic activities. The full-length cDNA encodes a deduced 414-amino acid protein with a molecular mass of 46.56 kD. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. DRAK1 messenger RNA appears to be ubiquitously expressed in human tissues. Overexpression of DRAK1 induces apoptosis. It has been shown in vitro that DRAK1 is capable of autophosphorylation and of phosphorylating the myosin light chain as an exogenous substrate, and that the noncatalytic C terminus is crucial for full kinase activity.
Function:
Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.
Subcellular Location:
Nucleus.
Tissue Specificity:
Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas.
Post-translational modifications:
Autophosphorylated.
Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
Contains 1 protein kinase domain.
Database links:Entrez Gene: 420775Chicken
Entrez Gene: 9263Human
Entrez Gene: 100008622Rabbit
Omim: 604726Human
SwissProt: Q9UEE5Human
SwissProt: Q9GM70Rabbit
Unigene: 709489Human
Unigene: 2549Rabbit
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.