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货号： bs-7612R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7612R-AF555
- 英文名称
- Anti-HIPK4/AF555
- 中文名称
- AF555标记的同源相互作用蛋白激酶4抗体
- 别 名
- HIPK 4; HIPK4; HIPK4_HUMAN; Homeodomain interacting protein kinase 4; Homeodomain-interacting protein kinase 4.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 细胞凋亡 细胞周期蛋白 激酶和磷酸酶 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 69kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HIPK4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. The homeodomain-interacting protein kinases (HIPK1, HIPK2, HIPK3 and HIPK4) comprise a subfamily of kinase proteins that have a conserved protein kinase domain, as well as a separate domain that interacts with homeoproteins. HIPK4 (Homeodomain-interacting protein kinase 4) is a 616 amino acid protein that localizes to the cytoplasm and exists as two isoforms that are produced by alternative splicing events. Like other members of the HIPK family, HIPK4 functions as a protein kinase that catalyzes the ATP-dependent phosphorylation of target proteins and is thought to act as a corepressor of target transcription factors.
Function:
Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors.
Subcellular Location:
Cytoplasm (By similarity).
Post-translational modifications:
Autophosphorylated (By similarity).
Similarity:
Belongs to the protein kinase superfamily. CMGCSer/Thr protein kinase family. HIPK subfamily.
Contains 1 protein kinase domain.
Database links:Entrez Gene: 147746Human
Entrez Gene: 233020Mouse
Entrez Gene: 308449Rat
Omim: 611712Human
SwissProt: Q8NE63Human
SwissProt: Q3V016Mouse
SwissProt: Q4V793Rat
Unigene: 79363Human
Unigene: 429716Mouse
Unigene: 41008Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.