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货号： bs-7642R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7642R-AF555
- 英文名称
- Anti-AGTRAP/AF555
- 中文名称
- AF555标记的血管紧张素Ⅱ受体相关蛋白抗体
- 别 名
- Angiotensin Ⅱ receptor associated protein; Angiotensin Ⅱ type I receptor associated protein; ATI receptor associated protein; ATRAP; MGC29646; Type 1 angiotensin Ⅱ receptor associated protein; ATRAP_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 信号转导 G蛋白偶联受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Horse, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 17kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human AGTRAP
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
AGTRAP (Angiotensin II receptor-associated protein) interacts with the angiotensin II type 1 receptor and negatively regulates type 1 angiotensin II receptor-mediated signaling, by regulating receptor internalisation as well as mechanisms of receptor desensitization such as phosphorylation.
Function:
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Subunit:
Interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1.
Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
Tissue Specificity:
Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
Database links:Entrez Gene: 57085 Human
Omim: 608729 Human
SwissProt: Q6RW13 Human
Unigene: 464438 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.