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货号： bs-7643R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7643R-AF555
- 英文名称
- Anti-ARTS1/AF555
- 中文名称
- AF555标记的脂肪细胞源性亮氨酸氨基肽酶抗体（血管内皮细胞生长因子诱导蛋白）
- 别 名
- Endoplasmic reticulum aminopeptidase 1; A LAP; A-LAP; Adipocyte derived leucine aminopeptidase; Adipocyte-derived leucine aminopeptidase; ALAP; Aminopeptidase PILS; APPILS; ARTS 1; ARTS-1; Arts1; Endoplasmic reticulum aminopeptidase 1; ERAAP; ERAP 1; Erap1; ERAP1_HUMAN; PILS AP; PILS-AP; PILSA; PILSAP; Puromycin insensitive leucyl specific aminopeptidase; Puromycin-insensitive leucyl-specific aminopeptidase; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator; VEGF-induced aminopeptidase.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 免疫学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 107kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ARTS1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
Function:
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
Subunit:
Monomer. May also exist as a heterodimer; with ERAP2. Interacts with RBMX.
Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type II membrane protein (Probable).
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
N-glycosylated.
Similarity:
Belongs to the peptidase M1 family.
Database links:Entrez Gene: 51752 Human
Entrez Gene: 80898 Mouse
Entrez Gene: 80897 Rat
Omim: 606832 Human
SwissProt: Q9NZ08 Human
SwissProt: Q9EQH2 Mouse
SwissProt: Q9JJ22 Rat
Unigene: 716426 Human
Unigene: 83526 Mouse
Unigene: 22516 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.