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货号： bs-7865R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7865R-AF555
- 英文名称
- Anti-GPSM1/AF555
- 中文名称
- AF555标记的G蛋白信号调节蛋白1抗体
- 别 名
- Activator of G-protein signaling 3;AGS3;AGS3 homolog;C10a;G protein signaling modulator 1 (AGS3 like, C. elegans);G-protein-signaling modulator 1;GPSM1;GPSM1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 发育生物学 神经生物学 信号转导 细胞周期蛋白 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Horse, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 75kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GPSM1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
Function:
Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
Subunit:
Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact with GNAO1. Interacts with STK11/LKB1 and MACF1 (By similarity). Interacts with INSC/inscuteable and FRMPD1.
Subcellular Location:
Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Tissue Specificity:
Expressed in intestinal cells.
Post-translational modifications:
Phosphorylation regulates interaction with G(i/o) alpha.
Similarity:
Belongs to the GPSM family.
Contains 4 GoLoco domains.
Contains 9 TPR repeats.
Database links:Entrez Gene: 26086 Human
Entrez Gene: 67839 Mouse
Entrez Gene: 246254 Rat
Omim: 609491 Human
SwissProt: Q86YR5 Human
SwissProt: Q6IR34 Mouse
SwissProt: Q9R080 Rat
Unigene: 239370 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.