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货号： bs-7888R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7888R-AF555
- 英文名称
- Anti-Cyclin L/AF555
- 中文名称
- AF555标记的周期素L抗体
- 别 名
- Ania 6a; BM 001; CCNL 1; CCNL1; CCNL1_HUMAN; Cyclin L ania 6a; Cyclin L; Cyclin L gamma; Cyclin L1; Cyclin-L; Cyclin-L1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 细胞周期蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Sheep, Chimpanzee, mpanzee
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 60kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Cyclin L/CCNL1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.
Tissue specificity;Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
Function:
Transcriptional regulator which participates inregulating the pre-mRNA splicing process. Seems to be involved inthe regulation of RNA polymerase II (pol II). Functions inassociation with cyclin-dependent kinases (CDKs) and has a role inthe second step of splicing. May be a candidate proto-oncogene inhead and neck squamous cell carcinomas (HNSCC). Inhibited by theCDK-specific inhibitor p21.
Subunit:
Interacts with POLR2A via its hyperphosphorylatedC-terminal domain (CTD) (By similarity). Interacts with CDK11A,CDK11B, CDK12, CDK13 and SFRS2.
Subcellular Location:
Nucleus speckle (By similarity). Note=Morespecifically found in nuclear intrachromatin granules clusters(IGC), also called nuclear speckles, which are storage compartmentsfor nuclear proteins involved in mRNA processing (By similarity).
Tissue Specificity:
Ubiquitous with higher level in thymus.Overexpression in primary tumors of head and neck squamous cellcarcinomas (HNSCC).
Similarity:
Belongs to the cyclin family. Cyclin L subfamily.
Database links:
UniProtKB/Swiss-Prot: Q9UK58.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.