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货号： bs-7896R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7896R-AF555
- 英文名称
- Anti-MNAT1/AF555
- 中文名称
- AF555标记的细胞周期G1的相互作用蛋白抗体
- 别 名
- MNAT 1; CAP35; CDK activating kinase assembly factor MAT1; CDK7/cyclin H assembly factor; Cyclin G1 interacting protein; MAT1; Menage a trois; MNAT 1; p35; p36; RING finger protein 66; RING finger protein MAT1; RNF66; MAT1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 细胞周期蛋白 激酶和磷酸酶 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 36kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MNAT1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
MNAT1 (or menage a trois-1) is a subunit of the CAK complex which is a multisubunit protein that includes CDK7, cyclin H, as well as MNAT1. CAK (CDK-activating kinase) phosphorylates and thus activates CDKS (Cyclin-dependent kinases) which play an essential role in cell cycle control of eukaryotic cells.
Function:
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
Subunit:
Associates primarily with CDK7 and cyclin H to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
Subcellular Location:
Nucleus.
Tissue Specificity:
Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.
Similarity:
Contains 1 RING-type zinc finger.
Contains 1 UIM (ubiquitin-interacting motif) repeat.
Database links:Entrez Gene: 4331Human
Entrez Gene: 17420Mouse
Entrez Gene: 266713Rat
Omim: 602659Human
SwissProt: P51948Human
SwissProt: P51949Mouse
Unigene: 509523Human
Unigene: 246750Mouse
Unigene: 15168Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.