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货号： bs-8019R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8019R-AF555
- 英文名称
- Anti-ICMT/AF555
- 中文名称
- AF555标记的异戊烯半胱氨酸羧基甲基转移酶抗体
- 别 名
- CMT; HSTE14; Icmt; ICMT_HUMAN; Isoprenylcysteine carboxylmethyltransferase; MGC39955; MGC95322; MST098; MSTP098; pcCMT; PCMT; PPMT; Prenylated protein carboxyl methyltransferase; Prenylcysteine carboxyl methyltransferase; Protein-S-isoprenylcysteine O-methyltransferase; RP23-421E12.4; STE14; fcmt.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 32kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CMT/Icmt
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.Tissue specificity:Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.
Function:
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
Subcellular Location:
Endoplasmic reticulum membrane.
Tissue Specificity:
Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.
Similarity:
Belongs to the isoprenylcysteine O-methyltransferase family.
Database links:Entrez Gene: 23463 Human
Entrez Gene: 57295 Mouse
Entrez Gene: 170818 Rat
Omim: 605851 Human
SwissProt: O60725 Human
SwissProt: Q9EQK7 Mouse
SwissProt: Q9WVM4 Rat
Unigene: 515688 Human
Unigene: 277464 Mouse
Unigene: 48709 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Icmt酶是异戊烯途径中的一种关键酶，它能将甲基加到Ras上。这种甲基标签能使Ras到达细胞中的最终目的地，Icmt酶能发送不控制生长的信号，因此，Icmt蛋白在保持细胞中的致癌基因Ras的开启状态中起到重要作用。（Ras是细胞的一种正常的遗传成分，但是这种基因的突变能够致使它促进细胞的失控生长。而且，在一半的结肠癌和90％的胰腺癌中发生了Ras基因突变）。