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货号： bs-8475R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8475R-AF555
- 英文名称
- Anti-FBXL15/AF555
- 中文名称
- AF555标记的FBXL15蛋白抗体
- 别 名
- F box and leucine rich repeat protein 15; F box only protein 37; F box/LRR repeat protein 15; Fbl15; FBXO37; FLJ16137; JET; OTTHUMP00000020367; OTTHUMP00000059115; OTTHUMP00000059124; OTTHUMP00000059125; Pleckstrin and Sec7 domain protein; PSD; MGC11279; FXL15_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 33kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human FBXL15
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
FBXL15 probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors. FBL15 (F-box and leucine-rich repeat protein 15), also known as FBXL15, FBXO37, PSD or JET, is a 296 amino acid protein that contains one F-box domain and functions as a component of the SCF complex, possibly playing a role in the ubiquitination and subsequent degradation of target proteins.
Function:
Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.
Subunit:
Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1 and FBXL15.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the FBXL15 family.
Contains 1 F-box domain.
Contains 5 LRR (leucine-rich) repeats.
Database links:
UniProtKB/Swiss-Prot: Q9H469.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.