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货号： bs-9181R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9181R-AF555
- 英文名称
- Anti-Repetin/AF555
- 中文名称
- AF555标记的中间丝相关蛋白抗体
- 别 名
- Intermediate filament associated protein; RPTN; RPTN_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 细胞周期蛋白 细胞分化
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 91kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Repetin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Repetin is a 784 amino acid secreted protein that belongs to the S100-fused protein family. Repetin is an extracellular epidermal matrix protein that is expressed in the epidermis and at high levels in eccrine sweat glands, the inner sheaths of hair roots and the filiform papilli of the tongue. A multifunctional epidermal matrix protein, repetin is involved in the cornified cell envelope formation. Containing two EF-hand domains, repetin’s recombinant N-terminal domain binds calcium reversibly. Repetin and trichohyalin may compensate for absent loricrin. The repetin gene contains three exons, two introns and spans at least 5.6 kb. The repetin gene is conserved in cow, mouse and rat, and maps to human chromosome 1q21.3.
Function:
Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium.
Subcellular Location:
Secreted; extracellular space; extracellular matrix.
Tissue Specificity:
Repetin is a multifunctional epidermal matrix protein involved in the cornified cell envelope formation. It reversibly binds calcium. Expression is scattered in the normal epidermis but strong in the acrosyringium, the inner hair root sheat and in the filiform papilli of the tongue.
Post-translational modifications:
Potential substrate of transglutaminase. Some arginines are probably converted.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the S100-fused protein family.
Contains 2 EF-hand domains.
Database links:Entrez Gene: 126638 Human
Entrez Gene: 20129 Mouse
Omim: 613259 Human
SwissProt: Q6XPR3 Human
SwissProt: P97347 Mouse
Unigene: 376144 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.