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货号： bs-9252R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9252R-AF555
- 英文名称
- Anti-RNF130/AF555
- 中文名称
- AF555标记的环指蛋白130抗体
- 别 名
- GOLIATH; 2510042A13Rik; G1 related zinc finger protein; G1rp; G1RZFP; GP antibody MGC117241; MGC138647; MGC99542; R goliath; RING finger protein 130; GOLI_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 44kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RNF130
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF130 (ring finger protein 130), also known as GP, G1RZFP (G1-related zinc finger protein) or GOLIATH, is a 419 amino acid single-pass type I membrane protein that shares similarity with a Drosophila zinc-finger protein found in mesoderm known as g1. RNF130 contains one PA (protease associated) domain and a single RING-type zinc finger. Implicated in the regulation of growth factor withdrawal-induced apoptosis of myeloid precursor cells, RNF130 is encoded by a gene located on human chromosome 5q35.3 and mouse chromosome 11 B1.3.
Function:
May have a role during the programmed cell death of hematopoietic cells. Acts as an E3 ubiquitin-protein ligase.
Subcellular Location:
Membrane; Single-pass type I membrane protein (Potential). Cytoplasm.
Tissue Specificity:
Ubiquitously expressed. Highly expressed in leukocytes. Not expressed in erythroblasts.
Post-translational modifications:
In vivo measurements suggest this protein is glycosylated (PubMed:19159218). In contrast, in vitro experiments failed to detect glycosylation (PubMed:16549277).
Similarity:
Contains 1 PA (protease associated) domain.
Contains 1 RING-type zinc finger.
Database links:Entrez Gene: 55819 Human
Entrez Gene: 59044 Mouse
SwissProt: Q86XS8 Human
SwissProt: Q8VEM1 Mouse
SwissProt: Q6Y290 Rat
Unigene: 484363 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.