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货号： bs-9307R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9307R-AF555
- 英文名称
- Anti-CP110/AF555
- 中文名称
- AF555标记的中心体蛋白110抗体
- 别 名
- 110 kDa centrosomal protein; Centriole associated protein; Centriolin; Centrosomal protein 110 kDa; Centrosomal protein CP110; Centrosomal protein of 110 kDa; CEP1; CEP110; CP110; CP110_HUMAN; DKFZp781G1416; FAN; KIAA0419; CCP110.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 细胞周期蛋白 细胞分化
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 113kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CP110
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Necessary for centrosome duplication at different stages of procentriole formation. Collaborates with CEP97, being involved in the suppression of a cilia assembly program. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.
Function:
Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. [SUBUNIT]
Subunit:
Interacts with CALM1, CETN2, CEP76 and CEP97. Interacts with NEURL4 and CCNF; these interactions are not mutually exclusive and both lead to CCP110 ubiquitination and proteasome-dependent degradation. Via its interaction with NEURL4, may indirectly interact with HERC2. Interacts with KIF24, leading to its recruitment to centrioles.
Subcellular Location:
Cytoplasm, cytoskeleton, centrosome, centriole. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis.
Tissue Specificity:
Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
Post-translational modifications:
Phosphorylated by CDKs.
Ubiquitinated by the SCF(Cyclin F) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication.
Database links:Entrez Gene: 9738 Human
Omim: 609544 Human
SwissProt: O43303 Human
Unigene: 279912 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.