产品中心
当前位置：首页>产品中心Anti-AE2/AF555
货号： bs-9847R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9847R-AF555
- 英文名称
- Anti-AE2/AF555
- 中文名称
- AF555标记的阴离子交换蛋白2抗体
- 别 名
- AE 2; AE-2; AE2 anion exchanger; Anion exchange protein 2; Anion exchanger 2; B3A2_HUMAN; BND3L; EPB3L1; HKB3; MPB3L; Non-erythroid band 3-like protein; SLC4A2; Solute carrier family 4 member 2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 细胞生物 通道蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 137kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human AE2/SLC4A2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Primary canalicular bile undergoes a process of fluidization and alkalinization along the biliary tract that is influenced by several factors, including hormones, innervation/neuropeptides and biliary constituents. The excretion of bicarbonate at both the canaliculi and the bile ducts is an important contributor to the generation of bile-salt independent flow. Bicarbonate is secreted from hepatocytes and cholangiocytes through parallel mechanisms, which involve chloride efflux through activation of chloride channels and further bicarbonate secretion via AE2 (also designated SLC4A2)-mediated chloride/bicarbonate exchange. The AE2 protein regulates pH, chloride concentration, cell volume and transepithelial ion transport in many tissues. Gene silencing of AE2 causes a marked inhibition of unstimulated and secretin-stimulated chloride/bicarbonate exchange, which maintains the bile acid pool that is crucial for secretin to induce bicarbonate-rich choleresis.
Function:
Plasma membrane anion exchange protein of wide distribution.
Subcellular Location:
Membrane.
Similarity:
Belongs to the anion exchanger (TC 2.A.31) family.
Database links:Entrez Gene: 6522 Human
Omim: 109280 Human
SwissProt: P04920 Human
Unigene: 647069 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.