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货号： bs-9696R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9696R-AF555
- 英文名称
- Anti-C20orf19/AF555
- 中文名称
- AF555标记的20号染色体开放阅读框19抗体
- 别 名
- DKFZP586H021; HT013; KIZUNA; MGC102941; MGC141930; Uncharacterized protein C20orf19; KIZ_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 发育生物学 神经生物学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 75kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human KIZUNA/C20orf19
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Representing about 2% of human DNA, chromosome 20 consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought important for seminal production, and some viewed as potential targets for male contraception. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20. The C20orf19 gene product has been provisionally designated C20orf19 pending further characterization.
Function:
Centrosomal protein required for establishing a robustmitotic centrosome architecture that can endure the forces thatconverge on the centrosomes during spindle formation. Required forstabilizing the expanded pericentriolar material around thecentriole.
Subunit:
Interacts with AKAP9, CEP72, ODF2, PCNT and TUBGCP2.
Subcellular Location:
Cytoplasm, cytoskeleton, centrosome.Note=Localizes to centrosomes throughout the cell cycle. Aftercentrosome duplication, it usually remains associated only with themother centrosome, containing the older mature centriole andparticles surrounding it. During prophase, additional particlesaccumulate around both separating centrosomes. Does not accumulateat the microtubule minus ends, but instead localizes to thecentrosomes and centrosome-surrounding area in amicrotubule-independent and dependent manner, respectively.
Post-translational modifications:
Phosphorylation at Thr-379 by PLK1 is not needed forcentrosomal localization or pericentriolar material expansion butis indispensable for spindle-pole stabilization.
Similarity:
Belongs to the kizuna family.
Database links:Entrez Gene: 55857 Human
SwissProt: Q2M2Z5 Human
Unigene: 187635 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.