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货号： bs-9489R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9489R-AF555
- 英文名称
- Anti-C9ORF46/AF555
- 中文名称
- AF555标记的9号染色体开放阅读框46抗体
- 别 名
- FLJ14688; AD025; Chromosome 9 open reading frame 46; FLJ39176; Hypothetical protein LOC55848; MDS030; transmembrane protein C9orf46; Uncharacterized hematopoietic stem/progenitor cells protein MDS030; PLRKT_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 发育生物学 神经生物学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 17kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human C9ORF46
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
C9orf46 is a 147 amino acid transmembrane protein. The gene encoding C9orf46 maps to human chromosome 9, which consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias.
Function:
Receptor for plasminogen. Regulates urokinaseplasminogen activator-dependent and stimulates tissue-typeplasminogen activator-dependent cell surface plasminogenactivation. Proposed to be part of a local catecholaminergic cellplasminogen activation system that regulates neuroendocrineprohormone processing. Involved in regulation of inflammatoryresponse; regulates monocyte chemotactic migration and matrixmetallproteinase activation, such as of MMP2 and MMP9.
Subunit:
Interacts with PLAT and PLAUR (By similarity).
Subcellular Location:
Cell membrane; Multi-pass membrane protein.Note=Colocalizes on the cell surface with urokinase plasminogenactivator surface receptor/PLAUR (By similarity).
Tissue Specificity:
Expressed in peripheral blood cells andmonocytes. Expressed in adrenal medulla.
Database links:Entrez Gene: 55848 Human
SwissProt: Q9HBL7 Human
SwissProt: Q9D3P8 Mouse
Unigene: 584242 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.