产品中心
当前位置：首页>产品中心Anti-Synapsin III/AF555
货号： bs-11371R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11371R-AF555
- 英文名称
- Anti-Synapsin III/AF555
- 中文名称
- AF555标记的神经突触素3抗体
- 别 名
- SYN 3; SYN-3; SYN3; Synapsin 3; Synapsin3; Synapsin-3; cN28H9.2 (synapsin III); OTTHUMP00000028987; SYN3_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 63kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Synapsin III
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Synapsins are synaptic vesicle-associated phosphoproteins that regulate synaptic vesicle exocytosis and may be involved in synaptogenesis. Evidence suggests that Synapsin I, Synapsin II and Synapsin IIIa are ATP-binding proteins that are regulated by Ca2+ and calmodulin binding. Ca2+ has been shown to stimulate ATP binding to Synapsin I, to have no effect on Synapsin II and to inhibit Synapsin III. Synapsin I and Synapsin II both undergo alternative splicing to produce two forms of each protein, Synapsin la and lb and Synapsin IIa and IIb, respectively. Synapsin III gives rise to at least three isoforms: Synapsin IIIa, IIIb and IIIc. Synapsin III plays unique roles both in early axon outgrowth and in the regulation of synaptic vesicle trafficking. In cultured mouse hippocampal neurons, synapsin III is expressed early during development, with levels peaking seven days after plating and declining thereafter. Synapsin III is highly concentrated in growth cones.
Function:
Synapsin III may be involved in the regulation of neurotransmitter release and synaptogenesis. It shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. Synapsin III contains a unique domain, J, located between domains C and E. Based on the Synapsin III genes localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction.
Subunit:
Interacts with CAPON
Subcellular Location:
Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.
Tissue Specificity:
Neuron specific. Detected predominantly in brain.
Similarity:
Belongs to the synapsin family.
Database links:Entrez Gene: 8224 Human
Entrez Gene: 29130 Rat
Omim: 602705 Human
SwissProt: O14994 Human
SwissProt: O70441 Rat
Unigene: 608750 Human
Unigene: 162920 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.