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货号： bs-8609R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8609R-AF555
- 英文名称
- Anti-LGR6/AF555
- 中文名称
- AF555标记的G蛋白偶联受体6抗体
- 别 名
- GPCR LGR6; FLJ14471; Gonadotropin receptor; GPCR; Leucine-rich repeat-containing G protein-coupled receptor 6; Leucine-rich repeat-containing G-protein coupled receptor 6; Lgr6; LGR6_HUMAN; VTS20631.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Rabbit,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 104kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LGR6
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
G protein-coupled receptors (GPCRs), also designated seven transmembrane (7TM) receptors and heptahelical receptors, are a protein family which interact with G proteins (heterotrimeric GTPases) to synthesize intracellular second messengers such as diacylglycerol, cyclic AMP, inositol phosphates and calcium ions. Their diverse biological functions range from vision and olfaction to neuronal and endocrine signaling and are involved in many pathological conditions. The GPCR family represents the largest class of targets for modern drugs. Leucine-rich repeat-containing G protein-coupled receptor 6 (LGR6) is an orphan-A GPCR with an N-terminal ectodomain comprising variable leucine-rich repeats, a 7TM region and a unique C-terminal intracellular tail. The sequence of LGR6 is similar to TSHR, FSHR and LHR. LGR6 is predominantly expres-sed in the adrenal gland, ovary and uterus.
Function:
Orphan receptor.
Subcellular Location:
Cell membrane.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Contains 15 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain.
Database links:Entrez Gene: 59352 Human
Entrez Gene: 329252 Mouse
Entrez Gene: 498233 Rat
Omim: 606653 Human
SwissProt: Q9HBX8 Human
SwissProt: Q3UVD5 Mouse
Unigene: 497402 Human
Unigene: 279594 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.