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货号： bs-11405R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11405R-AF555
- 英文名称
- Anti-Relaxin 3 receptor 1/AF555
- 中文名称
- AF555标记的G蛋白偶联受体135/松弛素受体3抗体
- 别 名
- Relaxin Receptor 3; G protein coupled receptor GPCR135; G protein coupled receptor SALPR; G-protein coupled receptor SALPR; GPCR SALPR; GPCR 135; GPCR135; Gprotein coupled receptor SALPR; Relaxin 3 receptor 1; Relaxin 3 receptor1; Relaxin 3/INSL7 receptor 1; Relaxin 3/INSL7 receptor1; Relaxin family peptide receptor 3; Relaxin family peptide receptor3; Relaxin/insulin like family peptide receptor 3; Relaxin3 receptor 1; Relaxin3 receptor1; RL3 R1; RL3R 1; RL3R1; RLN3 receptor 1; RLN3 receptor1; RLN3R1; RXFPR3; SALP R; SALPR; somatostatin and angiotensin like peptide receptor; RL3R1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 51kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Relaxin Receptor 3 (11-58aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Relaxin Receptor 3 is a G protein-coupled receptor that binds Relaxin 3 and influences differentiation and maintenance of the nervous system. Relaxin Receptor 3 shares sequence similarity with somatostatin receptors and angiotensin receptors. It mediates central processing of sensory signals in the rat and is thought to be a modulator of stress responses. Relaxin Receptor 3 is present in the brain, with highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, and low level expression in cerebellum. In peripheral tissues there are high levels in adrenal glands and low levels in pancreas, salivery gland, placenta, mammary gland and testis.
Function:
GPCR SALPR, also known as Relaxin 3 Receptor 1 (RXFP3), is a G-protein coupled receptor that is one of the physiological targets for relaxin 3, an insulin-like hormone. Activation of GPCR SALPR results in phosphorylation of ERK1/2. GPCR SALPR has been implicated in anxiety and obesity. A role for relaxin 3 and GPCR SALPR in reproductive function through the hypothalamic-pituitary-gonadal (HPG) axis has also been described.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:Entrez Gene: 51289Human
Entrez Gene: 239336Mouse
Entrez Gene: 294807Rat
Omim: 609445Human
SwissProt: Q9NSD7Human
SwissProt: Q8BGE9Mouse
Unigene: 170146Human
Unigene: 209312Mouse
Unigene: 127658Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.