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货号： bs-11435R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11435R-AF555
- 英文名称
- Anti-Neurogranin/AF555
- 中文名称
- AF555标记的神经颗粒素抗体
- 别 名
- Calmodulin binding protein; Hng; NEUG(55-78); NEUG_HUMAN; Neurogranin (protein kinase C substrate); Ng; NG; NRGN; Protein kinase C substrate; RC3; BICKS.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 7.6kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NG/Neurogranin (30-78aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008].
Function:
Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium.
Tissue Specificity:
In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease.
Post-translational modifications:
Phosphorylated at Ser-36 by PHK
Similarity:
Belongs to the neurogranin family.
Contains 1 collagen-like domain.
Contains 1 IQ domain.
Database links:Entrez Gene: 616955Cow
Entrez Gene: 4900Human
Entrez Gene: 64011Mouse
Entrez Gene: 64356Rat
Omim: 602350Human
SwissProt: P35722Cow
SwissProt: Q92686Human
SwissProt: P60761Mouse
SwissProt: Q04940Rat
Unigene: 524116Human
Unigene: 335065Mouse
Unigene: 11236Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.