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货号： bs-11463R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11463R-AF555
- 英文名称
- Anti-Liprin alpha 1/AF555
- 中文名称
- AF555标记的酪氨酸磷酸酶受体相互作用蛋白Liprin α1抗体
- 别 名
- PPFIA1; LAR interacting protein 1; LIP 1; LIP.1; LIP1; LIPRIN; MGC26800; PPFIA 1; PPFIA1; Protein tyrosine phosphatase receptor type f polypeptide (PTPRF) interacting protein (liprin) alpha 1; Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 1; PTPRF interacting protein alpha 1; LIPA1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 136kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Liprin alpha 1 (141-190aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
- 产品介绍
- background:
The protein encoded by this gene is a member of the LARprotein-tyrosine phosphatase-interacting protein (liprin) family.Liprins interact with members of LAR family of transmembraneprotein tyrosine phosphatases, which are known to be important foraxon guidance and mammary gland development. This protein binds tothe intracellular membrane-distal phosphatase domain of tyrosinephosphatase LAR, and appears to localize LAR to cell focaladhesions. This interaction may regulate the disassembly of focaladhesion and thus help orchestrate cell-matrix interactions.Alternatively spliced transcript variants encoding distinctisoforms have been described. [provided by RefSeq, Jul 2008].
Function:
This protein is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions.
Subunit:
Forms homodimers and heterodimers with liprins-alpha andliprins-beta. Interacts with the second PTPase domain of PTPRD,PTPRF and PTPRS. Interacts with GIT1, KIF1A and GRIP1
Subcellular Location:
Cytoplasm. Note=Colocalizes with PTPRF atthe ends of focal adhesions most proximal to the cell nucleus.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the liprin family. Liprin-alpha subfamily.
Contains 3 SAM (sterile alpha motif) domains.
Database links:Entrez Gene: 8500Human
Entrez Gene: 233977Mouse
Entrez Gene: 293645Rat
Omim: 611054Human
SwissProt: Q13136Human
Unigene: 530749Human
Unigene: 708791Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.