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货号： bs-11600R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11600R-AF555
- 英文名称
- Anti-SOX8/AF555
- 中文名称
- AF555标记的核转录因子SOX8抗体
- 别 名
- SOX 8; Sox8; SOX8_HUMAN; SRY (sex determining region Y) box 8; SRY box 8; SRY box containing gene 8; Transcription factor SOX 8; Transcription factor SOX-8; Transcription factor SOX8.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 47kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SOX8 (101-200aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
Function:
May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5-[AT][AT]CAA[AT]G-3.
Subcellular Location:
Nucleus.
Tissue Specificity:
Contains 1 HMG box DNA-binding domain.
Similarity:
Contains 1 HMG box DNA-binding domain.
Database links:Entrez Gene: 30812 Human
Entrez Gene: 20681 Mouse
Entrez Gene: 302993 Rat
Omim: 605923 Human
SwissProt: P57073 Human
SwissProt: Q04886 Mouse
Unigene: 243678 Human
Unigene: 258220 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.