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货号： bs-11675R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11675R-AF555
- 英文名称
- Anti-UBXD2/AF555
- 中文名称
- AF555标记的UBX结构域域蛋白D2抗体
- 别 名
- Erasin; FLJ23318; KIAA0242; KIAA2042; UBX domain containing 1; UBX domain containing 2; UBX domain containing protein 2; UBXD 2; UBXDC 1; UBXDC1; UBXN4_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 Alzheimers
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 57kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human UBXD2 (201-300aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Erasin is an endoplasmic reticulum (ER) and nuclear envelope membrane protein. Expressed in a variety of tissues, such as brain, placenta, heart, liver, prostate, kidney, pancreas, lung and skeletal muscle, erasin contains one UBX domain and participates in the clearing of ERAD (endoplasmic reticulum-associated protein degradation) substrates. The UBX domain of erasin is responsible for mediating its direct interaction with VCP (valosin-containing protein), an AAA-ATPase molecular chaperone. In response to ER stress, erasin expression is induced. The knockdown of erasin expression leads to the inhibition of ERAD, suggesting an important function of erasin in the ERAD pathway. In addition, erasin may be involved in Alzheimer’s disease, as it is known to accumulate in neurofibrillary degenerating neurons in patients with Alzheimer’s disease.
Function:
UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP) and promotes ER-associated protein degradation (ERAD). Immunohistochemical staining of brain tissue from patients with Alzheimers disease and control subjects revealed that UBXD2 accumulates preferentially in neurons undergoing neurofibrillary degeneration in Alzheimers disease.
Subunit:
Directly interacts with VCP.
Subcellular Location:
Endoplasmic reticulum membrane. Both the N- and the C-terminus face the cytosol; also found in the nucleus envelope contiguous to the ER.
Tissue Specificity:
Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 1 UBX domain.
Database links:Entrez Gene: 476130 Dog
Entrez Gene: 23190 Human
Entrez Gene: 67812 Mouse
Entrez Gene: 304766 Rat
Omim: 611216 Human
SwissProt: Q92575 Human
SwissProt: Q8VCH8 Mouse
SwissProt: Q5HZY0 Rat
Unigene: 709238 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.