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货号： bs-19217R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19217R-AF488
- 英文名称
- Anti-Neurochondrin/AF488
- 中文名称
- AF488标记的神经软骨蛋白NCDN1抗体
- 别 名
- AU042419; KIAA0607; M-Sema F-associating protein of 75 kDa; MGC93259; MMS10-AE; Ms10ae; NCDN; NCDN-1; Neurochondrin 1; Norbin; OTTHUMP00000065369; OTTHUMP00000065370; OTTHUMP00000065371; Sfap75.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 79kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Neurochondrin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2008]
Function:
Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling By similarity. Required for the spatial learning process. Acts as a negative regulator of Ca2+-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.
Subcellular Location:
Cytoplasm. Cell projection, dendrite.
Tissue Specificity:
Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine.
Similarity:
Interacts with SEMA4C, DIAPH1 (via FH3 domain) and GRM5 By similarity. Interacts with MCHR1.
Database links:Entrez Gene: 23154 Human
Entrez Gene: 505994 Cow
Entrez Gene: 26562 Mouse
Entrez Gene: 89791 Rat
Omim: 608458 Human
SwissProt: Q2KJ97 Cow
SwissProt: Q9UBB6 Human
SwissProt: Q91YH7 Mouse
SwissProt: O35095 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.