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货号： bs-23090R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-23090R-AF488
- 英文名称
- Anti-PURA/AF488
- 中文名称
- AF488标记的富含嘌呤元件结合蛋白A抗体
- 别 名
- PUR ALPHA; PUR1; purA; PURA_HUMAN; PURALPHA; Purine rich element binding protein A; Purine rich single stranded DNA binding protein alpha; Purine-rich single-stranded DNA-binding protein alpha; Transcriptional activator protein PUR alpha; Transcriptional activator protein Pur-alpha.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 转录调节因子 结合蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 35kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PURA
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Function:
This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the PUR DNA-binding protein family.
Database links:Entrez Gene: 5813 Human
Entrez Gene: 19290 Mouse
Entrez Gene: 307498 Rat
Omim: 600473 Human
SwissProt: Q00577 Human
SwissProt: P42669 Mouse
SwissProt: P86252 Rat
Unigene: 443121 Human
Unigene: 231802 Mouse
Unigene: 482241 Mouse
Unigene: 41055 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.