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货号： bs-20566R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20566R-AF488
- 英文名称
- Anti-BCNG1/AF488
- 中文名称
- AF488标记的脑环核苷酸门控通道蛋白1/HCN1抗体
- 别 名
- HCN1; BCNG1; Brain cyclic nucleotide gated channel 1; HAC2; Hyperpolarization activated cyclic nucleotide gated potassium channel 1; Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 神经生物学 通道蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 99kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human BCNG1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Hyperpolarization activated cation channels of the HCN gene family such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarisation and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
Function:
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli.
Subunit:
Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Predominantly expressed in brain. Highly expressed in apical dendrites of pyramidal neurons in the cortex, in the layer corresponding to the stratum lacunosum-moleculare in the hippocampus and in axons of basket cells in the cerebellum. Expressed in a subset of elongated cells in taste buds.
Post-translational modifications:
N-glycosylated.
Similarity:
Belongs to the immunoglobulin superfamily. ICAM family.ontains 5 Ig-like C2-type (immunoglobulin-like) domains.
Database links:Entrez Gene: 348980 Human
Entrez Gene: 15165 Mouse
Entrez Gene: 84390 Rat
Omim: 602780 Human
SwissProt: O60741 Human
SwissProt: O88704 Mouse
SwissProt: Q9JKB0 Rat
Unigene: 353176 Human
Unigene: 650434 Human
Unigene: 343429 Mouse
Unigene: 21408 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.