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货号： bs-10719R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-10719R-AF488
- 英文名称
- Anti-CNOT6/AF488
- 中文名称
- AF488标记的CNOT6蛋白抗体
- 别 名
- carbon catabolite repression 4 protein; Carbon catabolite repressor protein 4 homolog; CCR4; CCR4 carbon catabolite repression 4 like; CCR4 carbon catabolite repression 4-like; CCR4-NOT transcription complex, subunit 6; CNOT6; Cytoplasmic deadenylase.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 63kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CNOT6
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
CNOT6 is a widely expressed subunit of the CCR4-NOT transcription complex. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription as well as mRNA degradation. Various subunits (e.g. CNOT1, CNOT3) are involved in influencing nuclear hormone receptor activities. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. CNOT6 belongs to the CCR4/nocturin family and contains three LRR (leucine-rich) repeats. In the cytoplasm, CNOT6 acts as a poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the Fos gene.
Function:
Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3-5 RNase activity. The CCR4-NOT complex functions as general transcription regulation complex (By similarity). In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any.
Subunit:
Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Interacts with UNR. Interacts with ZNF335.
Subcellular Location:
Cytoplasmic and Nuclear.
Similarity:
Belongs to the CCR4/nocturin family.
Contains 4 LRR (leucine-rich) repeats.
Database links:Entrez Gene: 57472 Human
Entrez Gene: 104625 Mouse
Entrez Gene: 287249 Rat
Omim: 608951 Human
SwissProt: Q9ULM6 Human
SwissProt: Q8K3P5 Mouse
SwissProt: Q6AXU9 Rat
Unigene: 608380 Human
Unigene: 247113 Mouse
Unigene: 431753 Mouse
Unigene: 93562 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.