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货号： bs-20841R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20841R-AF488
- 英文名称
- Anti-CCL27/AF488
- 中文名称
- AF488标记的皮肤T细胞虏获趋化因子抗体
- 别 名
- ALP; CTACK; C-C motif chemokine 27; CC chemokine ILC; Ccl27; CTAK; Cutaneous T cell attracting chemokine; Cutaneous T-cell-attracting chemokine; ESkine; IL 11 R alpha locus chemokine; IL-11 R-alpha-locus chemokine; PESKY; SCYA27; Skinkine; Small inducible cytokine A27; Small-inducible cytokine A27.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 免疫学 趋化因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 19kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse CCL27
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq].
Function:
Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.
Subunit:
Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization.
Subcellular Location:
Secreted.
Tissue Specificity:
Testis, thymus, placenta, ovary and skin.
Similarity:
Belongs to the intercrine beta (chemokine CC) family.
Database links:Entrez Gene: 100039863 Mouse
Entrez Gene: 100039939 Mouse
Entrez Gene: 100040048 Mouse
Entrez Gene: 20301 Mouse
Entrez Gene: 362505 Rat
SwissProt: Q9Z1X0 Mouse
Unigene: 335946 Mouse
Unigene: 425176 Mouse
Unigene: 484274 Mouse
Unigene: 6660 Mouse
Unigene: 78371 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CCL27是一种CC型趋化因子，又被称为Skinkine，ESkine和CTACK。CCL27基因位于人类染色体9，它与皮肤上归巢的记忆T淋巴细胞有关，并在T细胞介导的皮肤炎症中起着重要的作用。CCL27表达在许多组织，包括性腺，胸腺，胎盘和皮肤。其配体为CCR10,CCL27与接触性软疣病毒编码产生的蛋白质MC148有较高的同源性，但却与人疱疹病毒8型编码产生病毒巨噬细胞炎症蛋白-Ⅱ竞争结合受体CCR10。