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货号： bs-20614R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20614R-AF488
- 英文名称
- Anti-NRXN3/AF488
- 中文名称
- AF488标记的轴突蛋白3抗体
- 别 名
- Neurexin III-alpha; NRXN3; NRXN 3; NRXN-3; C14orf60; Neurexin 3; Neurexin3; Neurexin-3; Neurexin III; Neurexin III-alpha; Neurexin-3-alpha [Precursor]; NRX3A_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 细胞粘附分子 细胞膜蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 178kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NRXN3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]
Function:
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis.
Subunit:
The cytoplasmic C-terminal region binds to CASK. Binds to neuroligins NLGN1, NLGN2 and NLGN3.
Subcellular Location:
Membrane; Single-pass type I membrane protein (Potential).
Tissue Specificity:
Expressed in the blood vessel walls (at protein level).
Post-translational modifications:
Proccessed by alpha-secretase leading to the formation of an extracellular soluble protein as well as a C-terminal membrane-embedded fragment (CTF). Proteolysis of these CTFs by gamma-secretase releases intracellular domains (ICDs) and extracellular peptides.
Similarity:
Belongs to the neurexin family.
Contains 1 laminin G-like domain.
Database links:Entrez Gene: 9369 Human
Entrez Gene: 18191 Mouse
Entrez Gene: 116508 Rat
Omim: 600567 Human
SwissProt: Q9HDB5 Human
SwissProt: Q9Y4C0 Human
SwissProt: Q6P9K9 Mouse
SwissProt: Q8C985 Mouse
SwissProt: Q8CCT8 Mouse
SwissProt: Q07310 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.