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货号： bs-8695R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8695R-AF488
- 英文名称
- Anti-PRMT2/AF488
- 中文名称
- AF488标记的蛋白精氨酸甲基转移酶2抗体
- 别 名
- ANM2_HUMAN; EC 2.1.1.; histone arginine N methyltransferase PRMT2; Histone-arginine N-methyltransferase PRMT2; HMT 1; HMT1 (hnRNP methyltransferase S. cerevisiae) like 1; HMT1; HMT1 hnRNP methyltransferase like 1; hnRNP methyltransferase (S. cerevisiae) like 1; hnRNP methyltransferase like 1; Hrmt1l1; MGC111373; PRMT 2; PRMT2 alpha; prmt2; PRMT2 beta; PRMT2 gamma; PRMT2 protein; PRMT2L2; Protein arginine methyltransferase 2; Protein arginine N methyltransferase 2; Protein arginine N-methyltransferase 2; Zf2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 49kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PRMT2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- Function:
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
Subunit:
Self-associates. Interacts with RB1 and E2F1 (By similarity). Interacts with NCOA6 coactivator. Interacts (via SH3 domain) with PRMT8. Interacts with AR. Interacts with NFKBIA.Interacts with ESR1, ESR2, PGR, PPARG, RARA, RXRA and THRB.Interacts with HNRNPUL1.
Subcellular Location:
Cytoplasm. Nucleus. Translocates from the cytoplasm to the nucleus, after hormone exposure.
Tissue Specificity:
Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.
Similarity:
Belongs to the protein arginine N-methyltransferase family.
Contains 1 SH3 domain.
Database links:Entrez Gene: 3275Human
Entrez Gene: 15468Mouse
Entrez Gene: 499420Rat
Omim: 601961Human
SwissProt: P55345Human
SwissProt: Q9R144Mouse
Unigene: 154163Human
Unigene: 32020Mouse
Unigene: 145566Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.