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货号： bs-7141R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7141R-AF488
- 英文名称
- Anti-Ricin B chain/AF488
- 中文名称
- AF488标记的蓖麻毒素B链抗体
- 别 名
- Ricin toxin B chain;RCA 60; Ricin B lectin; Ricin chain B; Ricin precursor; rRNA N-glycosidase; RT B; RTB.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Reacts with Ricinus communis (Castor Bean plant).
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 29kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Ricin B chain
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- Function:
Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).
Subunit:
Disulfide-linked dimer of A and B chains.The B chain is composed of two domains, each domain consists of 3 homologous subdomains (alpha, beta, gamma).
Database links:
Entrez Gene: 8287993 Ricinus communis
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.