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货号： bs-12703R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12703R-AF488
- 英文名称
- Anti-Plakophilin 3/AF488
- 中文名称
- AF488标记的桥粒斑菲素蛋白3抗体
- 别 名
- PKP 3 ; PKP3 ; PKP3_HUMAN ; Plakophilin 3b ; Plakophilin-3 ; Plakophilin3.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 发育生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 87kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Plakophilin 3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Function:
May play a role in junctional plaques.
Subcellular Location:
Nucleus. Cell junction > desmosome. Nuclear and associated with desmosomes.
Tissue Specificity:
Found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues.
Similarity:
Belongs to the beta-catenin family.
Contains 8 ARM repeats.
Database links:Entrez Gene: 11187Human
Entrez Gene: 56460Mouse
Entrez Gene: 293619Rat
Omim: 605561Human
SwissProt: Q9Y446Human
SwissProt: Q9QY23Mouse
Unigene: 534395Human
Unigene: 350037Mouse
Unigene: 144803Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.