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货号： bs-12711R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12711R-AF488
- 英文名称
- Anti-Plakophilin 4/AF488
- 中文名称
- AF488标记的桥粒斑菲素蛋白4抗体
- 别 名
- Catenin 4 ; Catenin4 ; FLJ31261 ; FLJ42243 ; p0071 ; PKP 4 ; PKP4 ; PKP4_HUMAN ; Plakophilin-4 ; Plakophilin4.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 发育生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 132kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Plakophilin 4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila armadillo gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
Function:
May play a role in junctional plaques.
Subcellular Location:
Cell junction > desmosome. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the beta-catenin family.
Contains 9 ARM repeats.
Database links:Entrez Gene: 281406Cow
Entrez Gene: 8502Human
Entrez Gene: 227937Mouse
Entrez Gene: 295625Rat
Omim: 604276Human
SwissProt: Q99569Human
SwissProt: Q68FH0Mouse
Unigene: 407580Human
Unigene: 260938Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.