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货号： bs-12597R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12597R-AF488
- 英文名称
- Anti-PDIA6/AF488
- 中文名称
- AF488标记的蛋白二硫异构酶A6抗体
- 别 名
- Endoplasmic reticulum protein 5; ER protein 5; ERP5; P5; Protein disulfide isomerase A6; Protein disulfide isomerase associated 6; Protein disulfide isomerase family A member 6; Protein disulfide isomerase P5; Protein disulfide isomerase related protein; Thioredoxin domain containing 7 (protein disulfide isomerase); Thioredoxin domain containing protein 7; TXNDC7.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 转运蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 48kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PDIA6
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Protein disulfide isomerase (PDIA6) ia an enzyme belonging to the protein disulfide isomerase family. Structurally, it contains 2 thioredoxin domains and its function is to catalyze the rearrangement of -S-S- bonds in proteins.
Function:
May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
Subunit:
Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with MICA on the surface of tumor cells, leading to MICA disulfide bond reduction which is required for its release from tumor cells. Interacts with ITGB3 following platelet stimulation.
Subcellular Location:
Endoplasmic reticulum.
Tissue Specificity:
Expressed in platelets (at protein level).
Similarity:
Belongs to the protein disulfide isomerase family.
Contains 2 thioredoxin domains.
Database links:Entrez Gene: 10130Human
Entrez Gene: 71853Mouse
Entrez Gene: 286906Rat
Omim: 611099Human
SwissProt: Q15084Human
SwissProt: Q922R8Mouse
SwissProt: Q63081Rat
Unigene: 212102Human
Unigene: 222825Mouse
Unigene: 2685Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.