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货号： bs-19880R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19880R-AF488
- 英文名称
- Anti-PARIS/ZNF746/AF488
- 中文名称
- AF488标记的锌指蛋白ZNF746抗体
- 别 名
- PARIS; Parkin-interacting substrate; Zinc finger protein 746; ZN746_HUMAN; ZNF746.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 锌指蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 100kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PARIS/ZNF746
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- Function:
Transcription repressor that specifically binds to the 5-TATTTT[T/G]-3 consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.
Subcellular Location:
Cytoplasm. Nucleus. Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes.
Post-translational modifications:
Ubiquitinated by PARK2. Lys-48-linked polyubiquitination by PARK2 leads to degradation by the proteasome and may play a key role in regulation of neuron death.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 4 C2H2-type zinc fingers.
Contains 1 KRAB domain.
Database links:Entrez Gene: 155061Human
Entrez Gene: 69228Mouse
Entrez Gene: 312303Rat
Omim: 613914Human
SwissProt: Q6NUN9Human
SwissProt: Q3U133Mouse
Unigene: 24643Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.