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货号： bs-19751R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19751R-AF488
- 英文名称
- Anti-SH3BP4/AF488
- 中文名称
- AF488标记的SH3结构域结合蛋白4抗体
- 别 名
- BOG25; EH binding protein; EH binding protein 10; EH-binding protein 10; EHB10; SH3 domain binding protein 4; SH3 domain-binding protein 4; SH3B4_HUMAN; sh3bp4; Transferrin receptor trafficking protein; Transferrin receptor-trafficking protein; TTP.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 转运蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 107kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SH3BP4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008]
Function:
Functions in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis.
Subcellular Location:
Membrane > clathrin-coated pit. Cytoplasmic vesicle > clathrin-coated vesicle. Nucleus. Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.
Tissue Specificity:
Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).
Post-translational modifications:
Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2.
Similarity:
Contains 1 SH3 domain.
Database links:Entrez Gene: 520462Cow
Entrez Gene: 486172Dog
Entrez Gene: 100730563 Guinea pig
Entrez Gene: 100065797Horse
Entrez Gene: 23677Human
Entrez Gene: 98402Mouse
Entrez Gene: 100347097Rabbit
Entrez Gene: 64634Rat
Omim: 605611Human
SwissProt: Q9P0V3Human
SwissProt: Q921I6Mouse
SwissProt: Q9JJS5Rat
Unigene: 516777Human
Unigene: 170983Mouse
Unigene: 35396Rat
Unigene: 36062Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.