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货号： bs-16227R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-16227R-AF488
- 英文名称
- Anti-GALNTL4/AF488
- 中文名称
- AF488标记的GALNTL4蛋白抗体
- 别 名
- GalNAc T like protein 4; GalNAc T15; GLT18_HUMAN;GalNAc transferase 18; GALNT15; GALNT18; N acetylgalactosaminyltransferase 15 UDP N acetyl alpha D galactosamine:polypeptide; N acetylgalactosaminyltransferase like 4; N acetylgalactosaminyltransferase like protein 4 UDP N acetyl alpha D galactosamine:polypeptide; Polypeptide GalNAc transferase like protein 4; pp GaNTase like protein 4; Protein UDP acetylgalactosaminyltransferase like protein 4; Protein UDP acetylgalactosaminyltransferase like protein 4 UDP GalNAc:polypeptide; Putative polypeptide N acetylgalactosaminyltransferase like protein 4; UDP GalNAc:polypeptide N acetylgalactosaminyltransferase like protein 4.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 细胞类型标志物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 70kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GALNTL4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosaminyl) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in Golgi apparatus. GalNAc-TL4, also known as LGALS14 or polypeptide GalNAc transferase-like protein 4, is a 607 amino acid single-pass type II membrane protein belonging to the glycosyltransferase 2 family and GalNAc-T subfamily. Localizing to Golgi apparatus, GalNAc-TL4 utilizes manganese and calcium as cofactors and may assist with the transfer of N-acetyl-D-galactosamine to a serine or threonine residue on protein receptors. GalNAc-TL4 likely catalyzes the initial reaction in O-linked oligosaccharide biosynthesis and contains a ricin B-type lectin domain, which binds to GalNAc and contributes to glycopeptide specificity, and two conserved domains located in the glycosyltransferase region. The N-terminal domain, also known as domain A or GT1 motif, may be involved in manganese coordination and substrate binding while the C-terminal domain, also known as domain B or Gal/GalNAc-T motif, is likely involved in catalytic reaction and UDP-Gal binding. GalNAc-TL4 exists as two alternatively spliced isoforms.
Function:
GALNTL4 may catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
Subcellular Location:
Golgi Apparatus membrane; Single-pass type II membrane protein
Similarity:
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Contains 1 ricin B-type lectin domain.
Database links:Entrez Gene: 374378Human
Entrez Gene: 233733Mouse
Entrez Gene: 293181Rat
SwissProt: Q6P9A2Human
SwissProt: Q8K1B9Mouse
SwissProt: A1A5P1Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.