产品中心
当前位置：首页>产品中心Anti-eIF4H/AF488
货号： bs-14553R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-14553R-AF488
- 英文名称
- Anti-eIF4H/AF488
- 中文名称
- AF488标记的eIF4H蛋白抗体
- 别 名
- AU018978; D5Ertd355e; E430026L18Rik; Ef4h; eIF 4H; eIF-4H; EIF4H; eukaryotic translation initiation factor 4H; IF4H_HUMAN; KIAA0038; WBSCR1; Williams Beuren syndrome chromosomal region 1 protein homolog; Williams Beuren syndrome chromosome region 1; Williams-Beuren syndrome chromosomal region 1 protein; Williams-Beuren syndrome chromosome region 1; WSCR1
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 发育生物学 神经生物学 转运蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Orangutan
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 25kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human eIF4H
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Function:
Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
Subcellular Location:
Cytoplasm; perinuclear region.
Tissue Specificity:
The short isoform is the predominant isoform and is expressed alone in liver and skeletal muscle. Both isoforms are expressed in fibroblast, spleen, testis and bone marrow. Levels are high in lung and pancreas and low in heart, frontal cortex and kidney.
DISEASE:
Note=EIF4H is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of EIF4H may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
Similarity:
Contains 1 RRM (RNA recognition motif) domain.
Database links:Entrez Gene: 7458Human
Entrez Gene: 517409Cow
Entrez Gene: 22384Mouse
Entrez Gene: 288599Rat
Omim: 603431Human
SwissProt: Q1JPH6Cow
SwissProt: Q15056Human
SwissProt: Q9WUK2Mouse
SwissProt: Q5RBR8Orangutan
SwissProt: Q5XI72Rat
Unigene: 520943Human
Unigene: 27955Mouse
Unigene: 79423Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.