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货号： bs-14301R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-14301R-AF488
- 英文名称
- Anti-DGKZ/AF488
- 中文名称
- AF488标记的甘油二酯激酶ζ/DGK-ζ抗体
- 别 名
- DAG kinase zeta; DAGK5; DAGK5 PEN; DAGK6; DGK ZETA; DGK-zeta; Dgkz; DGKZ_HUMAN; Diacylglycerol kinase zeta; Diglyceride kinase zeta; hDGKzeta.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 信号转导 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Guinea Pig,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 124kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DGKZ
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]
Function:
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.
Subcellular Location:
Cytoplasm. Nucleus. Cell membrane.
Tissue Specificity:
Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.
Post-translational modifications:
Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.
Similarity:
Belongs to the eukaryotic diacylglycerol kinase family.
Contains 2 ANK repeats.
Contains 1 DAGKc domain.
Contains 2 phorbol-ester/DAG-type zinc fingers.
Database links:Entrez Gene: 8525Human
Entrez Gene: 423197Chicken
Entrez Gene: 483635Dog
Entrez Gene: 100050499Horse
Entrez Gene: 104418Mouse
Entrez Gene: 81821Rat
Omim: 601441Human
SwissProt: Q13574Human
SwissProt: Q80UP3Mouse
SwissProt: O08560Rat
Unigene: 502461Human
Unigene: 314923Mouse
Unigene: 11208Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.