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货号： bs-14297R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-14297R-AF488
- 英文名称
- Anti-DGKG/AF488
- 中文名称
- AF488标记的甘油二酯激酶γ/DGK-γ抗体
- 别 名
- DAG kinase gamma; DAGK3; DGK gamma; DGKG; DGKG_HUMAN；diacylglycerol kinase gamma 90kDa; Diacylglycerol kinase gamma; Diglyceride kinase; Diglyceride kinase gamma.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 89kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DGKE
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
DGKG (Diacylglycerol kinase gamma ) reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid. This enzyme initiates resynthesis of phosphoinositides consumed by phospholipase C during cellular signal transduction. DGK gamma is one of multiple DGK isozymes found in animal cells. It is expressed abundantly in the human retina and to a much lesser extent in the brain. Other tissues contain extremely low levels.
Subcellular Location:
Cell Membrane and Cytoplasmic.
Database links:Entrez Gene: 1608Human
Entrez Gene: 110197Mouse
Entrez Gene: 25666Rat
Omim: 601854Human
SwissProt: P49619Human
SwissProt: Q2M1H4Human
SwissProt: Q5FWG1Human
SwissProt: Q91WG7Mouse
SwissProt: P49620Rat
Unigene: 683449Human
Unigene: 194986Mouse
Unigene: 10544Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.