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货号： bs-10308R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-10308R-AF488
- 英文名称
- Anti-JAZF1/AF488
- 中文名称
- AF488标记的JAZF1抗体
- 别 名
- JAZF zinc finger 1; JAZF1; JAZF1_HUMAN; Juxtaposed with another zinc finger protein 1; TAK1 interacting protein 27; TAK1-interacting protein 27; TIP27; Zinc finger protein 802; ZNF802.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Pig, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 27kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human JAZF1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]
Function:
Potential transcription factor.
Subunit:
Interacts with TAK1.
DISEASE:
Note=A chromosomal aberration involving JAZF1 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with SUZ12. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer. Translocation t(6;7)(p21;p22) with PHF1.
Similarity:
Contains 3 C2H2-type zinc fingers.
Database links:Entrez Gene: 221895 Human
Entrez Gene: 231986 Mouse
Entrez Gene: 685879 Rat
Omim: 606246 Human
SwissProt: Q86VZ6 Human
SwissProt: Q80ZQ5 Mouse
SwissProt: Q5RDF5 Orangutan
Unigene: 368944 Human
Unigene: 386865 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
II型糖尿病是危害很大的疾病，科学家们最近又鉴定出了6个参与II型糖尿病有关的基因。其中JAZF1基因同时在II型糖尿病和前列腺癌中都起作用，但糖尿病和前列腺癌的变异处于基因的不同位置。这些研究将会帮助我们揭示复杂的糖尿病基础，提示治疗和预防这个疾病的更好新方法。