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货号： bs-13962R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13962R-AF488
- 英文名称
- Anti-Collagen IX/AF488
- 中文名称
- AF488标记的胶原蛋白9抗体
- 别 名
- Collagen alpha 1(IX) chain; Collagen type IX alpha 1; EDM6; MED; STL4.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 89kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Collagen IX
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Type IX collagen proteoglycan is a major component of hyaline cartilages where it is located on the surface of the collagen fibrils so that a collagenous domain of the molecule (called COL 3) and a non-collagenous domain (called NC4) project at periodic distances away from the surface of the fibrils.
Function:
Structural component of hyaline cartilage and vitreous of the eye.
Subunit:
Heterotrimer of an alpha 1(IX), an alpha 2(IX) and an alpha 3(IX) chain.
Subcellular Location:
Secreted, extracellular space, extracellular matrix (By similarity).
Tissue Specificity:
Cytoplasmic
Post-translational modifications:
Covalently linked to the telopeptides of type II collagen by lysine-derived cross-links.
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
DISEASE:
Multiple epiphyseal dysplasia 6 (EDM6) [MIM:614135]: A generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.
Contains 10 collagen-like domains.
Contains 1 laminin G-like domain.
Database links:Entrez Gene: 1297Human
Entrez Gene: 12839Mouse
Entrez Gene: 305104Rat
Omim: 120210Human
SwissProt: P20849Human
SwissProt: Q05722Mouse
SwissProt: P20850Rat
Unigene: 590892Human
Unigene: 154662Mouse
Unigene: 90726Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.